- Merck Reemerges With a Bold AIDS Vaccine Effort -
Jon Cohen - KEYSTONE, COLORADO--Over the past few years, scientists from Merck & Co. have quietly built an AIDS vaccine research program that has fundamentally altered the landscape of this beleaguered field. At a scientific meeting here this week, Merck researchers described a comparison of various AIDS vaccine approaches in more than 100 monkeys. What most dazzled researchers here is the sheer scale of the company's AIDS vaccine effort, an endeavor that has attracted scant interest from other big pharmaceutical companies.
Science 292, Number 5514, Issue of 6 April 2001
& Oxidant Stress
- LONGEVITY: Growing Old Together - Evelyn
Strauss - Science Apr 6 2001: 41-43. [Summary]
- How Do Cells Sense Oxygen? Hao Zhu and H.
Published online April 5 2001; 10.1126/science.1060849 (Science
Express Perspectives ) [Abstract]
- Regulation of Longevity and Stress Resistance by Sch9 in Yeast.
Paola Fabrizio, Fabiola Pozza, Scott D. Pletcher, Christi M.
Gendron, and Valter D. Longo Published online April 5 2001;
10.1126/ science. 1059497 (Science Express Reports ) [Abstract]
a Palace for Research on Aging Buck
Institute applies multidisciplinary program to the science of growing old.
The Scientist 15:1, Feb. 5, 2001
- Ageing: Yeast longevity gene goes public - DAVID GEMS -
Changes in gene silencing throughout life might be a general phenomenon
underlying ageing and longevity: this mechanism is at work in yeast and,
as new work suggests, nematode worms.Nature
News & View March 8, 2001 Full text
- Increased dosage of a sir-2
gene extends lifespan in Caenorhabditis elegans HEIDI A. TISSENBAUM
AND LEONARD GUARENTE - Nature
410, 227 - 230 (2001)
in aging research - An identity crisis helps broaden the field (Scientist,
genome offers clues to longevity - Arabidopsis
can survive the loss of an enzyme that prevents aging. Drug Discovery
- Living with Genome Instability: Plant Responses to Telomere Dysfunction.
Karel Riha, Thomas D. McKnight, Lawrence R. Griffing, and Dorothy
E. Shippen. Science
2001 March 2; 291: 1797-1800.
do we grow old and die rather than stay young and gorgeous forever (&
three theories of aging)? - Henry Gee Nature Science Update 10/2/00
Leonard Guarente: Searching for Genes to Slow the Hands of
Biological Time (New York times 9/26/00). Times article is in reference
the paper by Lin
SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for Life-Span
Extension by Calorie Restriction in Saccharomyces cerevisiae. Science.
2000 Sep 22;289(5487):2126-2128. Related
drugs extend lifespan – in nematodes
(Drug Discovery Online 9/7/2000). This is media discussion of paper by Melov
S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC,
Malfroy B, Doctrow SR, Lithgow GJ. Extension of Life-Span with
Superoxide Dismutase/Catalase Mimetics. Science. 2000 Sep
Genomics, & Other
- Bioinformatics: Key to 21st Century Biology
(Robert W. Wallace, HMS Beagle 3/30/01, Issue 99)http://news.bmn.com/hmsbeagle/99/notes/adapt
Model for Alzheimers Illuminates Mysterious Neurotransmitter, Say
first schizophrenia gene is discovered...EurekAlert!
Lab Expanding Mouse Program Short
Course outlines post-genome research. The Scientist 14:8,
Sep. 4, 2000
Beyond the First Draft Making the genome data useful may depend on the
public project Ensembl - Scientific American
- Life after Worms
Lynx Therapeutics, Inc. - Sydney Brenner & Megaclone
(WA Wells, HMS Beagle).
Stein Makes Annotation Easy (9/00)
worms turn to claim Internet fame - Developmental biologists love Caenorhabditis
elegans, all 959 cells of it. Now researchers have given the little
darling its own Web site. Last
year, it became the first organism to have its entire genome sequenced,
and it will be posted on the site for all biologists to view. WormBase
will be written so that biologists beyond the 1,500 regular researchers
will be able to understand it, and it will be the home of a vertical
database that integrates all types of information. Butler, D. 2000. .
Beagle 5/6/00 - Nature 404(6777):425. You
can now access all the components of the fabulous WormBase interface via C. elegans menu at elegansNet.
- Private Company Sequences Human Genome
(New York Times; 5/6/00).
- New technology updates the house call
- A technological advance is giving new meaning to the words house call. Americans who need their health monitored regularly are finding a lifeline at the end of a phone line (MSNBC; 5/6/00).
Triumphant Treatment - Scientists have reported success against cancer
using a technique called antisense technology that halts malignant genes
at their roots (Washington Post; 4/5/00)
How to cope with the flood of bioinformation (HMS
NY Times (3//7/00)
since 1/7/2000, elegansNet is updated at the
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send questions and comments to elegansNet@hotmail.com
modified on 05/08/2001 10:17 AM