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Drug Discovery - elegansNet Selected Publications

 
  John P. Moore and Mario - New targets for inhibitors of HIV-1 replication - Nature Reviews, Drug Discovery, 4/01
  David J. Matthews and Jenny Kopczynski - Using model-system genetics for drug-based target discovery [Research Focus] - Drug Discovery Today, 2001, 6:3:141-149
 
P.E. Kuwabara and A. Coulson. RNAi Prospects for a General Technique for Determining Gene Function [Techniques]  Parasitology Today, 2000, 16:8:347-349
  Mark Cockett, Nicholas Dracopoli and Elliott Sigal. Applied genomics: integration of the technology within pharmaceutical research and development [Review] Current Opinion in Biotechnology, 2000, 11:6:602-609
 
David B. Searls. Using bioinformatics in gene and drug discovery [Research focus] Drug Discovery Today, 2000, 5:4:135-143. 
  Cockett M, Dracopoli N, Sigal E. Applied genomics: integration of the technology within pharmaceutical research and development.Curr Opin Biotechnol. 2000 Dec;11(6):602-9. Related Articles
  Black T, Hare R. Will genomics revolutionize antimicrobial drug discovery?
Curr Opin Microbiol. 2000 Oct;3(5):522-7. Related Articles
  Debouck C, Metcalf B. The impact of genomics on drug discovery.
Annu Rev Pharmacol Toxicol. 2000;40:193-207. Review Related Articles
  Johnson DE, Wolfgang GH. Predicting human safety: screening and computational approaches. Drug Discov Today. 2000 Oct 1;5(10):445-454. Related Articles
  PDeadman J. roteinase inhibitors and activators strategic targets for therapeutic intervention. J Pept Sci. 2000 Sep;6(9):421-31. Related Articles
  Evans DB, Traxler P, Garcia-Echeverria C. Molecular approaches to receptors as targets for drug discovery. EXS. 2000;89:123-39. Related Articles
  Gane PJ, Dean PM. Recent advances in structure-based rational drug design.
Curr Opin Struct Biol. 2000 Aug;10(4):401-4.  Related Articles
  Pevzner PA, Sze SH. Combinatorial approaches to finding subtle signals in DNA sequences. Ismb. 2000;8:269-78. Related Articles
  Nitric oxide (NO)-related pharmaceuticals: contemporary approaches to therapeutic NO modulation. Free Radic Biol Med. 2000 May 15;28(10):1495-506. Review. Related Articles
  Sautel M, Milligan G. Molecular manipulation of G-protein-coupled receptors: a new avenue into drug discovery. Curr Med Chem. 2000 Sep;7(9):889-96. Review. Related Articles
  Findeis MA. Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization. Biochim Biophys Acta. 2000 Jul 26;1502(1):76-84. Review. Related Articles
  Huang Z. Structural chemistry and therapeutic intervention of protein-protein interactions in immune response, human immunodeficiency virus entry, and apoptosis. Pharmacol Ther. 2000 Jun;86(3):201-15. Review. Related Articles
  Emilien G, Ponchon M, Caldas C, Isacson O, Maloteaux JM. Impact of genomics on drug discovery and clinical medicine. QJM. 2000 Jul;93(7):391-423. Review. Related Articles
  Bakhtiar R, Tse FL High-throughput chiral liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2000;14(13):1128-35. Related Articles
  Morelli MA. Industry viewpoint on thresholds for genotoxic carcinogens.
Toxicol Pathol. 2000 May-Jun;28(3):396-404. Review. Related Articles
  Houghten RA. Parallel array and mixture-based synthetic combinatorial chemistry: tools for the next millennium. Annu Rev Pharmacol Toxicol. 2000;40:273-82. Review. Related Articles
  Houghten RA, Wilson DB, Pinilla C. Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. Drug Discov Today. 2000 Jul;5(7):276-285. Related Articles
  Floyd CD, Leblanc C, Whittaker M. Combinatorial chemistry as a tool for drug discovery. Prog Med Chem. 1999;36:91-168. Review. Related Articles
  Roychoudhury S, Blondelle SE, Collins SM, Davis MC, McKeever HD, Houghten RA, Parker CN. Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase. Related Articles
  Browne MJ. Analysis of large gene databases for discovery of novel therapeutic agents. J Biotechnol. 2000 Mar 31;78(3):247-50. Related Articles
  Bodor N. Recent advances in retrometabolic drug design and targeting approaches.
Pharmazie. 2000 Mar;55(3):163-6. Review. Related Articles
  Brem S. Angiogenesis and Cancer Control: From Concept to Therapeutic Trial.
Cancer Control. 1999 Oct;6(5):436-458. Related Articles
 
Christopher J Rawlings, David B Searls.  Computational gene discovery and human disease [Review article] Current Opinion in Genetics & Development 1997, 7:416-423.
   
   

Updated: 06/10/2004 ; Created: 1/20/00

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