|Nitric Oxide & Oxidative Stress|
NO in Plants
Nitric oxide (NO) can mediate cellular effects through the second messenger cGMP or by direct interaction with target proteins. The mechanisms of direct interaction of NO with target proteins includes S-nitrosylation of thiol-containing proteins and tyrosine nitration, as well as direct interaction of NO with metal-containing proteins. NO signaling is essential for pathogen defense pathways in plants. Navarre et al. have discovered that tobacco aconitase (an iron-sulfur-containing enzyme) is inhibited in vitro by NO via a direct interaction. Animal aconitases play an important role in regulating cellular metabolism in response to oxidative stress and in regulating iron homeostasis by controlling translation of iron-responsive genes. It remains to be determined whether the plant aconitases have similar functions.
Navarre, D.A., Wendehenne, D., Durner, J., Noad, R., and Klessig, D.F. (2000) Nitric oxide modulates the activity of tobacco aconitase. Plant Phys. 122: 573-582.[Abstract] [Full Text]
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