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NO Releasing Agents 
1. S-nitrosopenicillamine
Wiegant FA, Malyshev IY, Kleschyov AL, van Faassen E, Vanin AF. Related Articles
Dinitrosyl iron complexes with thiol-containing ligands and S-nitroso-D,L-penicillamine as inductors of heat shock protein synthesis in H35 hepatoma cells.
FEBS Lett. 1999 Jul 16;455(1-2):179-82.
PMID: 10428497; UI: 99355451
: Iesaki T, Gupte SA, Wolin MS. Related Articles
A flavoprotein mechanism appears to prevent an oxygen-dependent inhibition of cGMP-associated nitric oxide-elicited relaxation of bovine coronary arteries.
Circ Res. 1999 Nov 26;85(11):1027-31.
PMID: 10571533; UI: 20040163
FEBS Lett 1994 May 30;345(2-3):177-80 Related Articles, Books

Kinetics and equilibria of S-nitrosothiol-thiol exchange between glutathione, cysteine, penicillamines and serum albumin.

Meyer DJ, Kramer H, Ozer N, Coles B, Ketterer B

Department of Biochemistry and Molecular Biology, University College, London, UK.

The kinetics and equilibria of S-nitrosothiol-thiol (SNO-SH) exchange reactions were determined using differential optical absorption. At pH 7.4 and 37 degrees C, k2 values ranged from 0.9 M-1.s-1 for the reaction between S-nitroso-glutathione (GSNO) and N-acetyl-penicillamine, and up to 279 M-1.s-1 for the exchange between S-nitroso-penicillamine (penSNO) and GSH. SNO-SH exchange involving GSH/GSNO and cysteine/cySNO was relatively rapid, k2 approx. 80 M-1.s-1 with an equilibrium constant slightly in favour of GSNO. GSNO was strongly favoured in equilibrium with penSNO, keq 0.0039. In the case of SNO-SH exchange between S-nitroso human serum albumin (albSNO) and GSH or cysteine k2 values were 3.2 and 9.1 M-1.s-1, respectively. The results show that the initial rate of SNO-SH exchange between physiological albSNO (7 microM) and venous plasma levels of GSH and cysteine is very slow, < 1%/min. On the other hand, if a nitrosothiol such as cySNO were to enter a cell, it would be rapidly converted to GSNO (43%/s).
J Pharmacol Exp Ther 1993 Sep;266(3):1497-500 Related Articles

Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide .

Venturini CM, Palmer RM, Moncada S

Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.

Endothelium-denuded strips of rabbit thoracic aorta relax on exposure to light. This response is similar to endothelium-dependent relaxation as it is inhibited by hemoglobin and methylene blue, and is mediated by an increase in cyclic GMP . We now demonstrate that photorelaxation decreases on repeated exposure to light. The response can be restored by treating the depleted smooth muscle strips with acidified nitrite, but not nitrite alone, and with the nitric oxide donors, S-nitrosopenicillamine and glyceryl trinitrate , but not with hydralazine. These data indicate that photorelaxation is mediated in part by a "pool" of light-activated vasodilator(s) and suggest that this may act as a store of nitric oxide which could play a role in the regulation of vascular tone.

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