Make your own free website on Tripod.com
NO Releasing Agents 
1. S-nitrosopenicillamine
Wiegant FA, Malyshev IY, Kleschyov AL, van Faassen E, Vanin AF. Related Articles
Dinitrosyl iron complexes with thiol-containing ligands and S-nitroso-D,L-penicillamine as inductors of heat shock protein synthesis in H35 hepatoma cells.
FEBS Lett. 1999 Jul 16;455(1-2):179-82.
PMID: 10428497; UI: 99355451
 
: Iesaki T, Gupte SA, Wolin MS. Related Articles
A flavoprotein mechanism appears to prevent an oxygen-dependent inhibition of cGMP-associated nitric oxide-elicited relaxation of bovine coronary arteries.
Circ Res. 1999 Nov 26;85(11):1027-31.
PMID: 10571533; UI: 20040163
 
FEBS Lett 1994 May 30;345(2-3):177-80 Related Articles, Books

Kinetics and equilibria of S-nitrosothiol-thiol exchange between glutathione, cysteine, penicillamines and serum albumin.

Meyer DJ, Kramer H, Ozer N, Coles B, Ketterer B

Department of Biochemistry and Molecular Biology, University College, London, UK.

The kinetics and equilibria of S-nitrosothiol-thiol (SNO-SH) exchange reactions were determined using differential optical absorption. At pH 7.4 and 37 degrees C, k2 values ranged from 0.9 M-1.s-1 for the reaction between S-nitroso-glutathione (GSNO) and N-acetyl-penicillamine, and up to 279 M-1.s-1 for the exchange between S-nitroso-penicillamine (penSNO) and GSH. SNO-SH exchange involving GSH/GSNO and cysteine/cySNO was relatively rapid, k2 approx. 80 M-1.s-1 with an equilibrium constant slightly in favour of GSNO. GSNO was strongly favoured in equilibrium with penSNO, keq 0.0039. In the case of SNO-SH exchange between S-nitroso human serum albumin (albSNO) and GSH or cysteine k2 values were 3.2 and 9.1 M-1.s-1, respectively. The results show that the initial rate of SNO-SH exchange between physiological albSNO (7 microM) and venous plasma levels of GSH and cysteine is very slow, < 1%/min. On the other hand, if a nitrosothiol such as cySNO were to enter a cell, it would be rapidly converted to GSNO (43%/s).
 
J Pharmacol Exp Ther 1993 Sep;266(3):1497-500 Related Articles

Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide .

Venturini CM, Palmer RM, Moncada S

Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.

Endothelium-denuded strips of rabbit thoracic aorta relax on exposure to light. This response is similar to endothelium-dependent relaxation as it is inhibited by hemoglobin and methylene blue, and is mediated by an increase in cyclic GMP . We now demonstrate that photorelaxation decreases on repeated exposure to light. The response can be restored by treating the depleted smooth muscle strips with acidified nitrite, but not nitrite alone, and with the nitric oxide donors, S-nitrosopenicillamine and glyceryl trinitrate , but not with hydralazine. These data indicate that photorelaxation is mediated in part by a "pool" of light-activated vasodilator(s) and suggest that this may act as a store of nitric oxide which could play a role in the regulation of vascular tone.
2. 
 
 

Introducing elegansNetRN: The Organism Bioinformatics & Research Menu Hubsite for Students, Teachers, Physicians, Biomedical Scientists, and the Public

elegansNet is webcasted from the following sites:

http://sites.netscape.net/elegansnet/  

http://members.tripod.com/C.elegans/

http://msnhomepages.talkcity.com/Terminus/elegansnet/ 

http://peds.mc.vanderbilt.edu/c_elegans/index.htm, 

http://www.geocities.com/elegansnet/index.htm

http://home.talkcity.com/PicassoPl/celegansnet/

 

elegansNet is viewed best with Internet Explorer 5.0 (small to medium font) or  later, is less compatible with other browsers.

Channel 1 (Left frame):  Index - The content is continuously evolving. Click on the main index menu items to be transported to submenu items.  This transport is fast because submenu options have already been downloaded to clients' computer. 

WM 2000 Abst.: EC MW W

West Coast WM Schedule 

Introduction

Announcements    Bionet
Career                      Feedback
Funding                  Literature
Meetings             Nematodes 
NetPublish NewsMedia
Search                    Software
What is New@elegansNet?
Anatomy                  Classroom
DB & Tools         Labs
Mat. Protocols Microarrays
References              Researchers

 Channel 2 (Main frame):  Notable recent abstracts are showcased in the context of the powerful PubMed interface of National Library of Medicine.  This expands the functionality of elegansNet workbench by  allowing easy literature searches on demand, and by providing continuous access to NCBI databases and services.

Channel 3 (Footnote frame):  The content which typically changes monthly highlights biomedical research technology, and introduces the elegansNet WebStars

Channel 4 (Header frame): The content is continuously evolving. The objective is to provide quick access to most frequently used sites for news, searches, dictionaries, and  bioinformatics databases & tools for many organisms.  A partial list includes: 

Quick Navigation of the Index Channel: 

Click on the main index menu items to be transported to submenu items.  This transport is fast because submenu options have already been downloaded to clients' computer. The following quick keys simplify navigation within the the index:

  • Back button of your browser or keyboard 

  • 'Home' & end' on your keyboard

  • 'alt + left arrow' or 'alt + right arrow' keys on your keyboard

  • Click any of the radio buttons distributed throughout the index

  • Press 'Ctrl + F' keys on your keyboard, and type key words into popup window to search the elegansNet index.

Search engines & elegansNet

Most public search engines (e.g., AltaVista) recognize the following Internet Keywords/"Real Names" and will direct you to elegansNet: 

elegansnet

elegans network

animal bioinformatics

animal research

research menu

menu hubsite

hubsite

 

 

Feedback 

Please send  questions and comments to elegansNet@hotmail.com

 

  

3/2000

 

Created 3.28.00

Contact Author/Editor

[last modified on 10/24/2002 10:26 PM ]  

Copyright Statements

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hit Counter