Make your own free website on
Nitric Oxide & Cell Death 
Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms  
Vilmante Borutaite, Ramune Morkuniene and Guy C. Brown

Volume 467, Issue 2-3, pp. 155-159
24 January 2000
[Abstract]   [Article Online]   [Article PDF]
We investigated to what extent different types of NO donors induce caspase activation by opening of the mitochondrial permeability transition pore (PTP) or inhibition of mitochondrial respiration. We found that nitrosothiols can directly open the PTP in isolated mitochondria and cause cytochrome c release, whereas NONOate donors can not. In macrophages nitrosothiols cause caspase activation that is blocked by cyclosporin A or calcium chelation, both of which prevent PTP opening, whereas caspase activation caused by NONOates is much less sensitive to these agents. Inhibitors of mitochondrial respiration did not promote PTP opening in isolated mitochondria, and although they cause caspase activation in macrophages, this activation was slower than that caused by NO donors, and was relatively insensitive to cyclosporin and calcium chelators suggesting that PTP opening was not involved.

Introducing elegansNetRN: The Organism Bioinformatics & Research Menu Hubsite

elegansNet is webcasted from the following sites:,


elegansNet is viewed best with Internet Explorer 5.0 (small to medium font) or  later, is less compatible with other browsers.

Channel 1 (Left frame):  Index - The content is continuously evolving. Click on the main index menu items to be transported to submenu items.  This transport is fast because submenu options have already been downloaded to clients' computer. 

WM 2000 Abst.: EC MW W

West Coast WM Schedule 


Announcements    Bionet
Career                      Feedback
Funding                  Literature
Meetings             Nematodes 
NetPublish NewsMedia
Search                    Software
What is New@elegansNet?
Anatomy                  Classroom
DB & Tools         Labs
Mat. Protocols Microarrays
References              Researchers

 Channel 2 (Main frame):  Notable recent abstracts are showcased in the context of the powerful PubMed interface of National Library of Medicine.  This expands the functionality of elegansNet workbench by  allowing easy literature searches on demand, and by providing continuous access to NCBI databases and services.

Channel 3 (Footnote frame):  The content which typically changes monthly highlights biomedical research technology, and introduces the elegansNet WebStars

Channel 4 (Header frame): The content is continuously evolving. The objective is to provide quick access to most frequently used sites for news, searches, dictionaries, and  bioinformatics databases & tools for many organisms.  A partial list includes: 

Quick Navigation of the Index Channel: 

Click on the main index menu items to be transported to submenu items.  This transport is fast because submenu options have already been downloaded to clients' computer. The following quick keys simplify navigation within the the index:

  • Back button of your browser or keyboard 

  • 'Home' & end' on your keyboard

  • 'alt + left arrow' or 'alt + right arrow' keys on your keyboard

  • Click any of the radio buttons distributed throughout the index

  • Press 'Ctrl + F' keys on your keyboard, and type key words into popup window to search the elegansNet index.

Search engines & elegansNet

Most public search engines (e.g., AltaVista) recognize the following Internet Keywords/"Real Names" and will direct you to elegansNet: 


elegans network

animal bioinformatics

animal research

research menu

menu hubsite





Please send  questions and comments to





Created 3.28.00

Contact Author/Editor

[last modified on 04/20/2003 04:09 PM ]  

Copyright Statements

















Hit Counter