& Complete Publications List
Deconstructing Aging -
Lisa Chong, Heather McDonald, and and Evelyn Strauss - Science
3 September 2004; 305: 1419 [DOI: 10.1126/science.305.5689.1419] (in
Introduction to special issue)
Longevity, Quality, and the One-Hoss Shay
Science 3 September 2004: 1369
to Grips With Bone Loss
Science 3 September 2004: 1420-1422
in Rhesus Monkeys: Relevance to Human Health Interventions
George S. Roth, Julie A. Mattison, Mary Ann Ottinger, Mark E. Chachich,
Mark A. Lane, and Donald K. Ingram
Science 3 September 2004: 1423-1426
Can Progeroid Syndromes Tell Us About Human Aging?
David Kipling, Terence Davis, Elizabeth L. Ostler, and Richard G. A.
Science 3 September 2004: 1426-1431
Research on Aging: The End of the BeginningGeorge
M. Martin, Kelly LaMarco, Evelyn Strauss, and Katrina L. KelnerScience
2003 February 28; 299: 1339-1341. (in Introduction to special issue)[Summary]
The price of tumour suppression? Nature 415, 26 - 27 (2002)
LONGEVITY: Growing Old Together
- Evelyn Strauss - Science Apr 6 2001: 41-43. [Summary]
Extension of Life-Span by Loss
of CHICO, a Drosophila Insulin Receptor Substrate Protein - David
J. Clancy, David Gems, Lawrence G. Harshman, Sean Oldham, Hugo
Stocker, Ernst Hafen, Sally J. Leevers, and Linda Partridge. Science
Apr 6 2001: 104-106. [Abstract]
A Mutant Drosophila
Insulin Receptor Homolog That Extends Life-Span and Impairs
Neuroendocrine Function - M. Tatar, A. Kopelman, D. Epstein,
M.-P. Tu, C.-M. Yin, and R. S. Garofalo. Science
Apr 6 2001: 107-110. [Abstract]
Ageing: Yeast longevity gene goes
public - DAVID GEMS - Changes in gene silencing throughout life
might be a general phenomenon underlying ageing and longevity: this
mechanism is at work in yeast and, as new work suggests, nematode
News & View March 8, 2001 Full text|PDF(142K)
Increased dosage of a sir-2
gene extends lifespan in Caenorhabditis elegans
HEIDI A. TISSENBAUM AND LEONARD GUARENTE - Nature
410, 227 - 230 (2001)
W. Walker; Gawain McColl; Nicole L. Jenkins; Jennifer Harris; Gordon
selection: Evolution of lifespan in C. elegans
Nature Volume 405 Number 6784 Page 296 - 297
It was proposed almost 50 years ago that ageing is
non-adaptive and is the consequence of a decli......Full
Text | PDF
Parkes TL, Hilliker AJ, Phillips JP, Motorneurons, reactive
oxygen, and life span in Drosophila
.Neurobiol Aging 1999 Sep-Oct;20(5):531-5. Related
Mitotic misregulation and human aging. Ly DH, Lockhart DJ, Lerner RA, Schultz PG
.Science 2000 Mar 31;287(5462):2486-92 Related
Isolating aging mutants: a novel method yields
three strains of the nematode Caenorhabditis elegans with extended
life spans. Yang Y, Wilson DL
- We designed a novel procedure for the isolation of mutant strains
with significantly increased life spans in the nematode
Caenorhabditis elegans. This procedure involves using heat-shock to
screen a large number of animals and isolate a few which are more
resistant to heat-shock stress. From the heat-shock-resistant
animals, three mutant strains, HG25, HG96, and HG246, all exhibiting
increased life span, were isolated. One mutant strain (HG246)
develops more slowly than the wild-type strain, N2. Two mutant
strains, HG96 and HG246, exhibit lower fertility than the wild-type.
Each of the three mutant strains has a normal appearance. Their
locomotive behavior also appears normal; only HG246 shows slightly
slower movement. Their feeding behavior appears normal, and the
males of HG25 and HG96 show normal mating behavior. However, the
males of HG246, either are defective in their mating ability or
their sperm are defective. The results indicate that heat-shock can
be used as a means to facilitate the isolation of mutants which have
longer life expectancy.Mech Ageing Dev 2000 Feb 7;113(2):101-16
Science 287, Jan 2000, p 54
AGING: Nota Bene: Sensing Old Age Orla Smith
We humans sense old age through feeling those creaky
joints or observing those graying hairs but, according to Apfeld and
Kenyon reporting in a recent issue of Nature (1), the nematode worm senses its age by smelling and tasting the environment. These investigators show that worms with defective olfactory organs (that would normally detect odor molecules in the environment) live longer than their comrades with a keener sense of smell. By comparing these worms with other mutant nematodes that live an unusually long time, the researchers found clues to how a reduced ability to "smell the roses" might lengthen life-span. The worm's olfactory sense
organs--amphids on the head and phasmids on the tail--are composed of a cluster of nerve cells, the ends of which are modified into cilia. The cilia are encircled by a sheath and a socket cell that form a pore in the worm's skin through which the tips of the cilia protrude (see photograph). Odor molecules and soluble compounds bind to G protein-coupled receptors (similar to the olfactory and taste receptors of mammals) located at the tip of each cilium. Worms with a poor sense of smell--because their olfactory organs have defective or absent cilia, blocked pores, or damaged sheaths--live much longer, yet are otherwise normal (for example, their feeding and reproductive behaviors are unchanged). Mutations in TAX-4--a channel regulated by cyclic GMP that sits under the G protein-coupled receptor and transduces the sensory signals into electrical impulses--also imbue the worm with a longer life. But mutations in the worm's olfactory machinery are not the only defects that extend its life-span. In an earlier study, Kenyon's group found that defects in the reproductive system could prolong life by decreasing the activity of DAF-2 (a receptor for an insulin-like molecule) and increasing the activity of DAF-16 (a transcription factor). By looking at worms defective in both sensory perception and reproduction, Apfeld and Kenyon worked out a putative pathway through which smell might influence a worm's longevity.
Regulation of lifespan by sensory perception in
Apfeld J, Kenyon C
Department of Biochemistry and Biophysics, University of California at
San Francisco, 94143-0448, USA.
Caenorhabditis elegans senses environmental signals through ciliated
sensory neurons located primarily in sensory organs in the head and
tail. Cilia function as sensory receptors, and mutants with defective
sensory cilia have impaired sensory perception. Cilia are
membrane-bound microtubule-based structures and in C. elegans are only
found at the dendritic endings of sensory neurons. Here we show that
mutations that cause defects in sensory cilia or their support cells,
or in sensory signal transduction, extend lifespan. Our findings imply
that sensory perception regulates the lifespan of this animal, and
suggest that in nature, its lifespan may be regulated by environmental
The PTEN tumor suppressor homolog in
Caenorhabditis elegans regulates longevity and dauer formation in an
insulin receptor-like signaling pathway.
Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H
homolog in C. elegans.
Conservation of the caenorhabditis elegans timing gene clk-1 from
yeast to human: a gene required for ubiquinone biosynthesis with
potential implications for aging.
Mamm Genome. 1999 Oct;10(10):1000-4.
[MEDLINE record in process]
PMID: 10501970; UI: 99431668
Genetic and environmental conditions that increase longevity in
Caenorhabditis elegans decrease metabolic rate.
Proc Natl Acad Sci U S A. 1999 Sep
PMID: 10500188; UI: 99432244
Mouse models of mitochondrial disease, oxidative stress, and
Mutat Res. 1999 Jul 30;434(3):233-42. Review.
PMID: 10486594; UI: 99416048
Proteoglycan distribution pattern during aging in the nematode
Caenorhabditis elegans: an ultrastructural histochemical study.
Histochem J. 1999 May;31(5):285-92.
PMID: 10461863; UI: 99388959
Recent advances on neuronal caspases in development and
Neurochem Int. 1999 Sep;35(3):195-220. Review.
PMID: 10458652; UI: 99385834
Bcl-xL is a negative regulator of caspase-3 activation in immature
neurons during development.
Brain Res Dev Brain Res. 1999 Aug 5;116(1):69-78.
PMID: 10446348; UI: 99376812
The daf-2 gene network for longevity regulates oxidative stress
resistance and Mn-superoxide dismutase gene expression in
FASEB J. 1999 Aug;13(11):1385-93.
PMID: 10428762; UI: 99357718
Neurosecretory control of aging in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7394-7.
PMID: 10377425; UI: 99307420
Carbonylated proteins in aging and exercise: immunoblot approaches.
Mech Ageing Dev. 1999 Mar 15;107(3):245-53. Review.
PMID: 10360680; UI: 99287425
Signals from the reproductive system regulate the lifespan of C.
Nature. 1999 May 27;399(6734):362-6.
PMID: 10360574; UI: 99287319
Ageing. A message from the gonads.
Nature. 1999 May 27;399(6734):308-9. No abstract
PMID: 10360568; UI: 99287313
A cytosolic catalase is needed to extend adult lifespan in C.
elegans daf-C and clk-1 mutants.
Nature. 1999 May 13;399(6732):162-6.
PMID: 10335847; UI: 99266878
Characterization of a life-extending mutation in age-2, a new aging
gene in Caenorhabditis elegans.
J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):B137-42.
PMID: 10219000; UI: 99233384
Regulation of dauer larva development in Caenorhabditis elegans by
daf-18, a homologue of the tumour suppressor PTEN.
Curr Biol. 1999 Mar 25;9(6):329-32.
PMID: 10209098; UI: 99227332
CLK-1 controls respiration, behavior and aging in the nematode
EMBO J. 1999 Apr 1;18(7):1783-92.
PMID: 10202142; UI: 99219857
Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate
methyltransferase (pcm-1) deletion mutants?
Arch Biochem Biophys. 1999 Apr 15;364(2):209-18.
PMID: 10190976; UI: 99208493
Tlk, a novel evolutionarily conserved murine serine threonine
kinase, encodes multiple testis transcripts.
Mol Reprod Dev. 1999 Apr;52(4):392-405.
PMID: 10092119; UI: 99190540
Regulation of the insulin-like developmental pathway of
Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2925-30.
PMID: 10077613; UI: 99178991
Protein carbonyl accumulation in aging dauer formation-defective
(daf) mutants of Caenorhabditis elegans.
J Gerontol A Biol Sci Med Sci. 1999 Feb;54(2):B47-51;
PMID: 10051850; UI: 99161002
Evolution of the RECQ family of helicases: A drosophila homolog,
Dmblm, is similar to the human bloom syndrome gene.
Genetics. 1999 Mar;151(3):1027-39.
PMID: 10049920; UI: 99160561
Expression patterns of the hepatic leukemia factor gene in the
nervous system of developing and adult mice.
Brain Res. 1999 Feb 27;820(1-2):1-11.
PMID: 10023025; UI: 99147857