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Aging Publications

Recent & Complete Publications List 

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  • David W. Walker; Gawain McColl; Nicole L. Jenkins; Jennifer Harris; Gordon J. Lithgow;Natural selection: Evolution of lifespan in C. elegans Nature Volume 405 Number 6784 Page 296 - 297 (2000)
    Summary: It was proposed almost 50 years ago that ageing is non-adaptive and is the consequence of a decli......Full Text | PDF

  • Parkes TL, Hilliker AJ, Phillips JP, Motorneurons, reactive oxygen, and life span in Drosophila .Neurobiol Aging 1999 Sep-Oct;20(5):531-5.  Related Articles

  • Isolating aging mutants: a novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans. Yang Y, Wilson DL - We designed a novel procedure for the isolation of mutant strains with significantly increased life spans in the nematode Caenorhabditis elegans. This procedure involves using heat-shock to screen a large number of animals and isolate a few which are more resistant to heat-shock stress. From the heat-shock-resistant animals, three mutant strains, HG25, HG96, and HG246, all exhibiting increased life span, were isolated. One mutant strain (HG246) develops more slowly than the wild-type strain, N2. Two mutant strains, HG96 and HG246, exhibit lower fertility than the wild-type. Each of the three mutant strains has a normal appearance. Their locomotive behavior also appears normal; only HG246 shows slightly slower movement. Their feeding behavior appears normal, and the males of HG25 and HG96 show normal mating behavior. However, the males of HG246, either are defective in their mating ability or their sperm are defective. The results indicate that heat-shock can be used as a means to facilitate the isolation of mutants which have longer life expectancy.Mech Ageing Dev 2000 Feb 7;113(2):101-16 Related Articles, Books

  • Science 287,  Jan 2000, p 54 AGING: Nota Bene: Sensing Old Age Orla Smith We humans sense old age through feeling those creaky joints or observing those graying hairs but, according to Apfeld and Kenyon reporting in a recent issue of Nature (1), the nematode worm senses its age by smelling and tasting the environment. These investigators show that worms with defective olfactory organs (that would normally detect odor molecules in the environment) live longer than their comrades with a keener sense of smell. By comparing these worms with other mutant nematodes that live an unusually long time, the researchers found clues to how a reduced ability to "smell the roses" might lengthen life-span. The worm's olfactory sense organs--amphids on the head and phasmids on the tail--are composed of a cluster of nerve cells, the ends of which are modified into cilia. The cilia are encircled by a sheath and a socket cell that form a pore in the worm's skin through which the tips of the cilia protrude (see photograph). Odor molecules and soluble compounds bind to G protein-coupled receptors (similar to the olfactory and taste receptors of mammals) located at the tip of each cilium. Worms with a poor sense of smell--because their olfactory organs have defective or absent cilia, blocked pores, or damaged sheaths--live much longer, yet are otherwise normal (for example, their feeding and reproductive behaviors are unchanged). Mutations in TAX-4--a channel regulated by cyclic GMP that sits under the G protein-coupled receptor and transduces the sensory signals into electrical impulses--also imbue the worm with a longer life. But mutations in the worm's olfactory machinery are not the only defects that extend its life-span. In an earlier study, Kenyon's group found that defects in the reproductive system could prolong life by decreasing the activity of DAF-2 (a receptor for an insulin-like molecule) and increasing the activity of DAF-16 (a transcription factor). By looking at worms defective in both sensory perception and reproduction, Apfeld and Kenyon worked out a putative pathway through which smell might influence a worm's longevity.

1 : Nature 1999 Dec 16;402(6763):804-9

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Regulation of lifespan by sensory perception in Caenorhabditis elegans.

Apfeld J, Kenyon C

Department of Biochemistry and Biophysics, University of California at San Francisco, 94143-0448, USA.

Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. elegans are only found at the dendritic endings of sensory neurons. Here we show that mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Our findings imply that sensory perception regulates the lifespan of this animal, and suggest that in nature, its lifespan may be regulated by environmental cues. 

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway.
Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H homolog in C. elegans.


Vajo Z, et al.

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Conservation of the caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging.
Mamm Genome. 1999 Oct;10(10):1000-4.
[MEDLINE record in process]
PMID: 10501970; UI: 99431668


Van Voorhies WA, et al.

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Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate.
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11399-403.
PMID: 10500188; UI: 99432244


Melov S, et al.

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Mouse models of mitochondrial disease, oxidative stress, and senescence.
Mutat Res. 1999 Jul 30;434(3):233-42. Review.
PMID: 10486594; UI: 99416048


Schimpf J, et al.

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Proteoglycan distribution pattern during aging in the nematode Caenorhabditis elegans: an ultrastructural histochemical study.
Histochem J. 1999 May;31(5):285-92.
PMID: 10461863; UI: 99388959


Marks N, et al.

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Recent advances on neuronal caspases in development and neurodegeneration.
Neurochem Int. 1999 Sep;35(3):195-220. Review.
PMID: 10458652; UI: 99385834


Urase K, et al.

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Bcl-xL is a negative regulator of caspase-3 activation in immature neurons during development.
Brain Res Dev Brain Res. 1999 Aug 5;116(1):69-78.
PMID: 10446348; UI: 99376812


Honda Y, et al.

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The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.
FASEB J. 1999 Aug;13(11):1385-93.
PMID: 10428762; UI: 99357718


Ailion M, et al.

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Neurosecretory control of aging in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7394-7.
PMID: 10377425; UI: 99307420


Goto S, et al.

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Carbonylated proteins in aging and exercise: immunoblot approaches.
Mech Ageing Dev. 1999 Mar 15;107(3):245-53. Review.
PMID: 10360680; UI: 99287425


Hsin H, et al.

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Signals from the reproductive system regulate the lifespan of C. elegans.
Nature. 1999 May 27;399(6734):362-6.
PMID: 10360574; UI: 99287319


Riddle DL.

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Ageing. A message from the gonads.
Nature. 1999 May 27;399(6734):308-9. No abstract available.
PMID: 10360568; UI: 99287313


Taub J, et al.

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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
Nature. 1999 May 13;399(6732):162-6.
PMID: 10335847; UI: 99266878


Yang Y, et al.

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Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans.
J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):B137-42.
PMID: 10219000; UI: 99233384


Rouault JP, et al.

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Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN.
Curr Biol. 1999 Mar 25;9(6):329-32.
PMID: 10209098; UI: 99227332


Felkai S, et al.

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CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.
EMBO J. 1999 Apr 1;18(7):1783-92.
PMID: 10202142; UI: 99219857


Niewmierzycka A, et al.

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Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants?
Arch Biochem Biophys. 1999 Apr 15;364(2):209-18.
PMID: 10190976; UI: 99208493


Shalom S, et al.

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Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts.
Mol Reprod Dev. 1999 Apr;52(4):392-405.
PMID: 10092119; UI: 99190540


Gil EB, et al.

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Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2925-30.
PMID: 10077613; UI: 99178991


Yasuda K, et al.

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Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans.
J Gerontol A Biol Sci Med Sci. 1999 Feb;54(2):B47-51; discussion B52-3.
PMID: 10051850; UI: 99161002


Kusano K, et al.

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Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene.
Genetics. 1999 Mar;151(3):1027-39.
PMID: 10049920; UI: 99160561


Hitzler JK, et al.

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Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice.
Brain Res. 1999 Feb 27;820(1-2):1-11.
PMID: 10023025; UI: 99147857

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