Pathway Pictures

Adhesion path pictures

• Integrin

AIDS, HIV, and Immune Sys pp

• Escape Artist Par Excellence
• Critical Path image library (ARIC's AIDS Medical Image Gallery)
• HIV Protease Structural Database
• UNAIDS slide collection - unaids.org

Biotechnology

Biotechnology

• From Gene to Function
• Building Blocks
• Chromosomes and Cell Division
• Biological Engineering
• Genetics
• Viruses
• Cell Processes

Calcium path picture

• Signaling: Dynamics, Homeostasis, and Remodeling - Nature Reviews 2003
• Two models for how the depletion of intracellular calcium stores might trigger the influx of calcium into a cell - Nature 2001.

Carbohydrates & Glycobiology

Carbohydrate,  & Glycobiology  Chemistry

• Carbohydrate Chemistry and Glycobiology: A Web Tour - 23 March 2001 Special Issue of Science
• Cellular processes in which O-GlcNAc has been implicated (PI-3 kinase, TATA-binding protein- associated factor (p110), c- myc (myc), estrogen receptor (ER), and RNA polymerase II (Pol II). Numbers in parentheses are reference numbers. 23 March 2001 Special Issue of Science

Cell Activation

Cell Activation: cell activation

• EPO
• FcER1
• PLC
• Insulin or secretion/transcription coupling
• IL-2
• IL-3
• IL-4
• TCR
• TNFR2

Cell Cycle Regulation

• Cell Cycle
• ATM
• Fas
• MAPK or Regulation by G protein-coupled receptors
• p53

Cell Signalling

Cell Signaling (U. Alabama server & many contributors) st

• Signal Transduction Overview
• Pathways of Extracellular Signaling Molecules
• Mammalian MAPK Signaling Pathways
• Insulin Receptor Signaling
• Inositol Signaling
• TGF-ß Receptor Signaling
• G-protein-coupled Receptor Database
• Cell Signaling Networks Database
• Protein Kinase Resource
• Database of Phosphorylation Sites
• Nuclear Receptor Resource
• Signaling to the Actin Cytoskeleton
• Scientific American: How Cancer Arises

Chromatin path pictures

Chromatin, Insulators Enhancers, Silencers, Promoters, Long Distance Interactions...

• DNA Binding Proteins: Classes & Properties
• NRDB (Nuclear Receptor Database)(UCSF)
• Nuclear Receptor Resources (Georgetown)
• Steroids & Receptors - William Messer, U. of Toledo.
• Nucleosome-dependent Gene Expression and Silencing in Yeast (YoungLab, Whitehead Inst.).
• Initiation Machinery (YoungLab, Whitehead Inst.)
• Steroid Receptor recycling & Molecular Chaperones (DeFranco & Csermely; STKE, 7/00).

Cytokines/chemokines path picture

• EGF
• IFN-a
• IFN-g
• IL-2
• IL-3
• IL-4
• IL-6
• IL-12
• PDGF
• TGF-b

Development path pictures

• Fas
• Heterochronic genes genetic pathway for control of temporal sequence of C. elegans cell lineage (Slack Lab, Yale U.)
• IGF-1
• p53
• Insulin or secretion/transcription coupling
• Wnt

DNA Replication

DNA Replication

• Helicase
• Primase
• Replication Fork
• SSB

Enhancers pictures

Enhancers pathpictures

• Modular/Nonmodular

Genes ST

• Wnt Gene Homepage

• BCR
• CD40L
• EPO
• IL-2
• IL-3
• IL-4
• TCR

• Immunological Synapse
• CD40L
• EGF
• EPO
• IFN-a
• IFN-g
• PDGF
• T Cell
• TCR
• TGF-b
• TLR4
• TPO Ion Channels p

Ion Channels path pictures

• Calcium 

Neuroscience

• Bioactive Peptides Induced Signaling Pathway
• Ion Channels & Phorbal Esters
  • Ion channels & Phorbal Esters
  • Receptor Cross Talk: Ligand-Gated Ion Channels Start to Communicate (STKE; 10/2000).
• MAPK or Regulation by G protein-coupled receptors
• NGF
• T Cell

Protein Degradation path pictu

• Apoptosis - Wilkinson lab
• Calcium-Activated Proteases (Calpains) in signal transduction - Wilkinson lab
• Cell-cycle Control and the Stress Response (Ubiquitin and Proteasomes) - Wilkinson lab
• Separation of sister chromatids during cell division in yeast - Nature 410, 882 - 885 (2001).

Protein Methylation path pictu

• A New Role for Protein Methylation: Switching Partners at the Phosphatase Ball (STKE, 24 April 2001) RNA Maturation p

RNAi

• miRNA vs. siRNA - see model

RNA Maturation path pictures

• Spliceosome - Nature 413, 583-584 (2001)

Transcription

• Transcription factors: The trans-regulators of promoters and enhancers (Gilbert SF)

• TRANSFAC database

• TRANSPATH - Gene- regulatory pathways.

Cinema

• C. elegans Movies - A visual introduction to C. elegans Normal Development, RNAi Screens, Adults, and Techniques representing researchers world wide including Hayman, Strome, White, Skop, Waddle, Hope, Knoble, Tsien, Schafer, Sternberg, and Ward (A Goldstein lab page).

• 'Fancy Movies' - Elegene  (QuickTime or Windows Media) - Titles Include: Running Worm, Larval; Adult Worm; Crowded Worms; Egg Laying; Microinjection of DNA; Pain Assay.

• GFP & Bioluminescence

• Virtual Embryo (Ed.: Leon Browder & Laurie Iten; Calgary U. & Purdue).

Labs

• Ambros lab - Worm Photo Gallery

• Avery lab - Pictures of Worms and Worm Pharynxes

• Blakely Lab - Molecular Genetics of Neurotransmitter Transport - The movie shows brightfield and fluorescence overlays of worms transgenic for GFP driven by the C. elegans dopamine transporter (DAT-1) promoter. 

• Driscoll Lab - Worm Photos and Drawings

• Nonet Lab Movies (Progressive view through SNARE complex; Defecation cycle; Trafficking of vesicles in pharyngeal gland cells; Images White's N2U series section).

• Riddle Lab - intestinal cells, sensory organs, excretory system, cuticle, dauer larvae

• Strome Lab 

  • Videos

  • photo archive

• Ward Lab:

  • Image and Video Gallery

  •   Transmission Electron Micrograph of a C. elegans Spermatozoon

• White Lab

  Movies -

  • First Cleavage - visualize male and female pronuclei approaching each other, fusing and ... (Ahna Skop, White lab, U.  Wisconsin - Madison).
  • Wild type Development
  • Cytoplasmic flow
  • Isolated P1 Blastomere
  • Rhodamine labeled tubulin in the early embryo
  • Segregation of P granules
  • WT, dnc-1 RNAi & dnc-2 RNAi
  • Stereo 4D Reconstruction of C. elegans embryos
  • Cell Fusions in the C.elegans Hypodermis
  • Fusing Membranes and Adherens Junctions
  • Hypodermal morphogenesis in stereo 4D
  • Tubulin-GFP in early C.elegans embryo

Parts Index -- Leon Avery's Server

• The whole parts list (List of all cells, 106k).
• Cells via acedb
• N2U serial electron micrographs
• Lineage drawing (from Nick Rhind)
  • Editable PICT file (Mac, binhexed self-extracting archive)
  • GIF image
• The nervous system:
  
  • Nervous system data
  • Richard Durbin's thesis
  • The Mind of a Worm